LRRC15
Is próitéin é seicheamh athfhillteach leoicín-mhar 15 nó LRRC15 atá ionchódaithe ag géine LRRC15 i ndaoine.[1] atá suite ar chrómasóim 3 ag 3q29 a bhaineann leis an forfhine LRR, a bhfuil baint aige le hidirghníomhaíochtaí cill-cill agus cill- siad micrithimpeallachta. Tá réamhfhianaise ann go bhféadfadh baint a bheith ag léiriú le déine COVID-19 agus gur fachtóir coisctheach é d’iontráil SARS-CoV-2 i gcealla. Níl fearainn incheallacha soiléir ag LRRC15. Léiríonn LRRC15 patrún léirithe, an-srianta, ach cuirtear in iúl é i réimsí a chomhdhéanann bacainní imdhíonachta ó dhúchas amhail an phlacaint, an craiceann, fibreablastaí gníomhachtaithe i gcréachtaí, agus fíocháin linfóideacha mar an liathán D’fhéadfadh ról éigin a bheith ag LRRC15 san imdhíonacht dhúchasach. Cuirtear LRRC15 in iúl go hiomrallach in ailse.
Tuilleadh léitheoireachta[cuir in eagar | athraigh foinse]
- "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein" (September 2003). Genes & Development 17 (17): 2094–107. doi:. PMID 12923058.
- "Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy" (February 2020). Cancer Discovery 10 (2): 232–253. doi:. PMID 31699795.
- "LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity" (September 2022). Nature 611 (7934): 148-154. doi:. PMID 36171287.
- "Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin" (November 2022). Cancer Cell 40 (11): 1392-1406. doi:. PMID 36270275.
- "Cross-tissue organization of the fibroblast lineage" (May 2021). Nature 593 (7860): 575–579. doi:. PMID 33981032. Bibcode: 2021Natur.593..575B.
- "LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation" (March 2018). Stem Cell Res Ther 9 (1): 65. doi:. PMID 29523191.
- "Expression and Clinical Implications of Leucine-Rich Repeat Containing 15 (LRRC15) in Osteosarcoma" (September 2020). J Orthop Res 38 (11): 2362–2372. doi:. PMID 32902907.
- "Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy" (June 2008). Journal of Virology 82 (12): 5933–9. doi:. PMID 18385238. PMC:2395123.
- "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid" (January 2002). Biochemical and Biophysical Research Communications 290 (2): 756–62. doi:. PMID 11785964.
- "Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix" (September 2005). Biochemical and Biophysical Research Communications 335 (2): 631–6. doi:. PMID 16098915.